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2 edition of Ion movements during contraction of the guinea pig ileum longitudinal smooth muscle. found in the catalog.

Ion movements during contraction of the guinea pig ileum longitudinal smooth muscle.

Marilyn Rosamond James

Ion movements during contraction of the guinea pig ileum longitudinal smooth muscle.

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Published by NationalLibrary of Canada in Ottawa .
Written in English


Edition Notes

Ph.D. thesis, University of British Columbia, 1977.

The Physical Object
Pagination3 microfiche
ID Numbers
Open LibraryOL19778513M

General. Histamine is an ubiquitous chemical messenger that can be released from a variety of cells (e.g. mast cells, enterochromaffin-like cells, neurones) to act on one of four histamine receptors: H 1, H 2, H 3 and H classification of histamine receptors has resulted from rigorous pharmacological analysis of the response of different isolated tissues and cells to . This book is particularly relevant in the understanding, diagnosis and management of irritable bowel syndrome – the most common functional disorder of the bowel. IBS has been diagnosed in % of adults in the US, and symptoms of IBS are responsible for more than 3 million visits to the physician in the US. The pharmacological profile of all compounds was derived on guinea-pig isolated left and right atria to evaluate their inotropic and/or chronotropic effects, respectively, and on K +-depolarized (80 mM) guinea-pig vascular (aortic strips) and nonvascular [ileum longitudinal smooth muscle (GPILSM)] to assess the calcium antagonist by: 4.


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Ion movements during contraction of the guinea pig ileum longitudinal smooth muscle. by Marilyn Rosamond James Download PDF EPUB FB2

The excitation-contraction-relaxation cycle of the guinea pig ileum longitudinal smooth muscle was studied in muscles contracted by a muscarinic agent, cismethyldimethylaminomethyl-1,3-dioxolane methiodide (CD) and by 60 mM KC1.

Aspects of the cycle were investigated by analyzing the active transport enzyme activities in the sarcolemma, the tissue Ca depots which. Isometric contractile responses to carbachol were studied in ileal longitudinal smooth muscle strips from wild-type mice and mice genetically lacking M 2 or M 3 muscarinic receptors, in order to characterize the mechanisms involved in M 2 and M 3 receptor-mediated contractile responses.

Single applications of carbachol (– μ M) produced concentration Cited by:   In guinea-pig ileal longitudinal muscle, muscarinic partial agonists, 4-(N-[3-chlorophenyl]-carbomoyloxy)butynyl-trimethylammonium (McN-A) and pilocarpine, each produced parallel increases in tension and cytosolic Ca 2+ concentration ([Ca 2+]c) with a higher EC 50 than that of the full agonist maximum response of [Ca 2+]c or tension Cited by:   The effect of botulinum C2 toxin was studied on the contractions of the guinea pig ileum myenteric plexus longitudinal muscle preparation.

Botulinum C2 toxin inhibited the muscle contraction induced by electrical stimulation (60 V; ms; Hz) in a time and concentration dependent manner. The inhibitory effect occurred with a Ion movements during contraction of the guinea pig ileum longitudinal smooth muscle.

book lag of about 1 h, and depended Cited by: How is Guinea Pig Ileum Longitudinal Smooth Muscle abbreviated. GPILSM stands for Guinea Pig Ileum Longitudinal Smooth Muscle.

GPILSM is defined as Guinea Pig Ileum Longitudinal Smooth Muscle very rarely. Physostigmine ( × 10 −8 m) potentiated the contraction of the longitudinal muscle elicited by dl ‐muscarine.

Hemicholinium‐3 (HC‐3) caused a rightward shift of the dose‐response curve to dl ‐muscarine on the ileal longitudinal muscle of the guinea‐pig ileum. 4Cited by: Disclaimer. All content on this website, including dictionary, thesaurus, literature, geography, and Ion movements during contraction of the guinea pig ileum longitudinal smooth muscle.

book reference data is for informational purposes only. We have previously reported (Allen & Carpenter, ) that inositol 1,4,5-trisphosphate (IP 3) causes a contraction of saponin-permeabilised guinea-pig ileum longitudinal smooth muscle.

Here we demonstrate that GTPγS also causes a contraction of permeabilised ileum longitudinal smooth muscle, though via a mechanism distinct from that of IP : M.

Allen, J. Carpenter. Ca 2+-DEPENDENT CONTRACTION OF SMOOTH MUSCLE. Contraction of smooth muscle is initiated by a Ca 2+-mediated change in the thick filaments, whereas in striated muscle Ca 2+ mediates contraction by changes in the thin filaments.

In response to specific Ion movements during contraction of the guinea pig ileum longitudinal smooth muscle. book in smooth muscle, the intracellular concentration of Ca 2+ increases, and this activator Ca 2+ combines Cited by: Specific binding of 3 H-substance P was studied in guinea-pig ileum longitudinal smooth muscle membranes.

A single population of non-interacting sites with an apparent dissociation constant of nM was observed. The relative potencies of some structural analogues of substance P, notably eledoisin and substance P (5–11), in competing for 3 H-substance P binding sites, Cited by: Recently, Kunze et al.

() showed that during direct intracellular recordings from the intrinsic primary sensory neurons in the guinea‐pig small bowel, the activity of such neurons was dependent upon the contraction and tone of the smooth muscle. Yet, it is unclear how contraction of the smooth muscles influences the propagation of Cited by: A functional role for the M2 muscarinic Ion movements during contraction of the guinea pig ileum longitudinal smooth muscle.

book in smooth muscle contraction was investigated in isolated guinea pig ileum. Contractile responses to the muscarinic agonist oxotremorine-M. Nasu T., Sakai N., Washibe T. and Ishida Y. () Cooling-induced contraction in ileal longitudinal smooth muscle of guinea-pig. Pharm. Pharmac.

36, Pandya K. () Effect of temperature reduction on canine trachea. smooth muscle response to Cited by: 7. Heterogeneity in the muscarinic receptor population of guinea pig ileum longitudinal smooth muscle was found in competition binding experiments against N-methyl[3H]scopolamine using either a cardioselective (AF-DX ) or a smooth muscle-selective (hexahydrosiladifenidol) antimuscarinic compound.

AF-DX recognized 65% of the total. 1. A method is described for measuring the rate of contraction of the longitudinal muscles of the intestine.

The rate of contraction of the guinea pig ileum with different concentrations of histamin and acetylcholine has been measured. Plotting the log 1/contraction time against the log molar concentration, a slightly concave line is obtained in both cases, the Author: Frederick Bernheim, Abner Gorfain.

The membrane potential of the separated longitudinal muscle of the guinea‐pig terminal ileum was recorded intracellularly with glass micro‐electrodes. In tissues kept at room temperature and then brought to 35° C for 15–30 min or about 1 hr, the fall in membrane potential upon changing to potassium‐free solution was ± mV Cited by:   We evaluated changes in contractility of the guinea‐pig isolated ileum, using intact segments and myenteric plexus‐longitudinal muscle (MPLM) preparations, after several times (5– min) of ischemia in situ.

Intestinal ischemia was produced by clamping the superior mesenteric by: during muscle contraction, actin and myosin filaments of fixed length slide past one another in an energy-requiring process, resulting in muscle contraction-during muscle contraction, each sarcomere shortens as the thin filaments slide inward between the thick filaments so that Z lines are pulled closer together.

Contraction of peristalsis. Relaxation of peristalsis. the constriction pushes food through the digestive tract. the contraction of circular and longitudinal muscle mixes the Wall of the gut is smooth muscle Consists of short cells. dose-dependent contraction of the smooth muscle of the guinea pig ileum with threshold values at 80 or mg/ml respectively.

2X M atropine or 2X M mepyramine individually caused a right shift on the cumulative concentration-response curve for each plant extract. All the results which will be described were obtained on the longitudinal muscle of the guinea-pig terminal ileum, separated from the underlying circular muscle, and placed in physiological salt solution at 35 'C.

All the records are of the membrane potential recorded intracellularly. Further details of the method are given elsewhere (Bolton I). Contractions and motility. The contractions of the circular and longitudinal muscles are regulated by electrical impulses that begin with the passage of calcium ions into the muscle duodenal pacemaker sends electrical impulses down the small intestine at a rate of 11 cycles per minute in the duodenum, gradually decreasing to 8 cycles per minute in the ileum.

A min treatment of longitudinal smooth muscle of guinea-pig ileum with propylbenzilylcholine mustard (PrBCM, 3 x 10(-6) M) irreversibly inhibited the responses elicited by carbachol. The role of histamine H1- H2- and H3-receptors was studied on neural transmission in ascending excitatory pathways of the guinea pig ileum.

A two-compartment (oral and anal compartments) bath was used: ascending neural pathways were activated by electrical stimulation in the anal compartment and the resulting contraction of the circular muscle in the Cited by: This study was to generate phasic and tonic stress-strain curves for evaluation of smooth muscle function in the obstructed guinea pig jejunum.

Partial and sham obstruction of the jejunum in guinea pigs was created surgically, with guinea pigs not being operated on served as normal controls. The animals survived 2, 4, 7, and 14 days, by: 3.

The transmural stimulation, given to the guinea pig ileum acts on enteric nervous system lining the gastrointestinal system controlling GIT, produces an action potential at the membrane causing depolarisation and permeable to calcium (ca+2) ion and leads to increase in ca+2 ion concentration through voltage gated ca +2 channel.

In this experiment pharmacological effect of acetylcholine and carbachol are studied by using an isolated tissue preparation, which is a guinea pig ileum. The contractile property of the smooth muscle is used for the straightforward measurement of the force it produces as an indication of effect.

The ileum is a part of the intestines among the. A computer simulation program to teach the effects of drugs and electrical stimulation on the enteric nervous system.

This program simulates an isolated preparation of the guinea pig ileum, a smooth muscle preparation exhibiting little spontaneous contractile activity, which is extensively used for pharmacological studies. The effects of various smooth muscle relaxing drugs on contractile responses to acetylcholine (ACh), Ba 2+ and Ca 2+, and on the tissue cyclic AMP levels were examined in the guinea pig rine and theophylline caused a decrease both in the maximum height and the slope of dose-response curves induced by the three stimulants, and an increase in the cyclic AMP Cited by: The current understanding is that longitudinal muscle contraction begins before and outlasts circular muscle contraction during esophageal peristalsis in normal subjects.

The goal of our study was to reassess the relationship between the contractility of two muscle layers using novel ways to look at the muscle by: I need to prepare for and then write up an experiment about Guinea Pig Ileum contractions using an organ bath. Can anyone recommend any good textbooks that outline this procedure.

The experiment involves a 2cm piece of ileum in Tyrodes Solution. During the contraction of a muscle, even during a single twitch, the struc-ture may shorten by 30 percent of its original length or more, and the actin and myosin filaments must therefore slide past each other (in a frog muscle starting at a resting sarcomere length of microns) by microns (that is, angstroms)in eachhalf-sarcomere.

Stretch-activated neuronal pathways to longitudinal and circular muscle in guinea pig distal colon. Am J Physiol Gastrointest Liver Physiol G–G, Link ISI Google Scholar; 26 Spencer NJ and Smith TK.

Simultaneous intracellular recordings from longitudinal and circular muscle during the peristaltic reflex in guinea-pig distal by: A link between airway smooth muscle (ASM) and airway hyperresponsiveness (AHR) in asthma was first postulated in the midnineteenth century, and the suspected link has garnered ever increasing interest over the years.

AHR is characterized by excessive narrowing of airways in response to nonspecific stimuli, and it is the ASM that drives this by: 4. How does KCl actually cause a contraction in smooth muscle.

- such as what are the receptors it binds to. - anything to do with calcium and how it depolarises to cause contraction. I can't seem to find enough info on this and really need help please. The inner, circularly-arranged layer of smooth muscle cut in cross-section, as it is here, presents a longitudinal view of the muscle cells.

Note the paucity of connective tissue in smooth muscle. Individual smooth muscle cells are surrounded by connective tissue (an endomycium), which you may be able to resolve.

Ion distribution and ion movements in smooth muscle 35 R. CASTEELS, G. DROOGMANS AND H. HENDRICKX Action of acetylcholine on the longitudinal muscle of guinea-pig ileum: the role of an electrogenic sodium pump EDITH BtLBRING) F.R.S.

AND H. KURIYAMA The action of catecholamines on guinea-pig taenia coli J. FURNESS AND M. COSTA. Pharmacological reactivity of guinea pig ileum to aqueous extract of Solanum aethiocpicum was determined in vitro.

Extract of the vegetable contracted the isolated ileum in a dose dependent fashion. These contractions were inhibited by mepyramine (5xM) cimetidine (5 x M)and atropine (5xM) inferring.

The gastrointestinal tract (digestive tract, alimentary canal, digestion tract, GI tract, GIT) is an organ system within humans and other animals which takes in food, digests it to extract and absorb energy and nutrients, and expels the remaining waste as mouth, esophagus, stomach and intestines are part of the gastrointestinal tract.

Latin: Tractus digestorius (mouth to anus), canalis. Contraction of the _____ alters the shape of the intestinal lumen and moves epithelial pleats and folds. rings of smooth muscle, called _____, regulate the movement of materials along internal passageways. _____ are longitudinal bands of smooth muscle in the colon wall.

Definition. Taenia coli. Free flashcards pdf help memorize facts about BIO - Final Review 1 - Q & A's from Online Lessons & Labs - Muscle Tissue. Other activities to help include hangman, crossword, word scramble, games, matching, quizes, and tests.During this period, the organ bath solution was refreshed download pdf 15 min.

The ileum contractions were induced by KCl (60 mM), acetylcholine (ACh, 1 μM) or BaCl 2 (4 mM) and once the plateau of contraction elicited by spasmogens was achieved, extract was added to the organ bath cumulatively (, 1, 2 and 4 mg mL-1).

Hi, I'm studying about peristalsis for ebook bio test. My textbook says that ebook the longitudinal muscles contracts and the circular muscles of the intestine relaxes, the lumen is widened and shortened, and thus food can pass through more easily. This is preceded by the muscle contractions the other way round, causing the lumen to constrict and push the food .